Publications by authors named "Alina Xcaret Rubio-Sanchez"
Unraveling the non-fitness status of NK cells: Examining the NKp30 receptor and its isoforms distribution in HIV/HCV coinfected patients.
Cecilia Gutiérrez-Iñiguez Paulina Cervantes-Rodríguez Luz Alicia González-Hernández Jaime Federico Andrade-Villanueva Gloria Yareli Gutiérrez-Silerio
Mol Immunol
August 2024
Article Synopsis
- HIV/HCV coinfection leads to faster liver damage due to dysregulation of natural killer (NK) cells, which are important for blocking HCV replication and preventing fibrosis.
- In a study, HCV-infected patients showed more liver damage than those with HIV alone, with a notable decrease in NKp30 isoform A expression and other NK cell markers in HIV/HCV patients.
- Understanding these dysfunctional NK cell parameters in HIV and HCV patients can help develop new treatments to enhance NK cell activity and reduce liver damage.
Background: COVID-19 emerged in late 2019 and has occasioned more than 765 millions cumulative cases and 6.9 millions of deaths globally. Notably, around 70% of patients with severe COVID-19 are men.
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