Publications by authors named "Alina Schultze-Berndt"
Left ventricular noncompaction (LVNC) is a ventricular wall anomaly morphologically characterized by numerous, excessively prominent trabeculations and deep intertrabecular recesses. Accumulating data now suggest that LVNC is a distinct phenotype but must not constitute a pathological phenotype. Some individuals fulfill the morphologic criteria of LVNC and are without clinical manifestations.
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- Left ventricular noncompaction cardiomyopathy (LVNC CMP) is a genetic heart condition with unclear links between genetic variants and clinical outcomes in both children and adults, making it a subject of study.
- A multicenter retrospective study of 149 LVNC CMP patients over 30 years identified 134 genetic variants, with 40% diagnosed before age 18, revealing that most variants are of unknown significance and do not effectively stratify risk for major adverse cardiac events (MACE).
- Key findings showed that reduced left ventricular systolic function significantly increases the risk of MACE, with patients exhibiting this reduced function being 4.6 times more likely to experience serious cardiac events.