Publications by authors named "Alina S Chabina"
Article Synopsis
- Human pluripotent stem cells (hPSCs) can differentiate into any adult tissue, making them important for regenerative medicine and research into factors affecting their growth and characteristics.
- The study analyzed the migration patterns of three hPSC cell lines (AD3, CaSR, and H9) through bright-field imaging, focusing on their "good" and "bad" morphological phenotypes.
- Results showed that migration speed varied based on the cell line and growth environment, with notable differences in migration behavior between "good" and "bad" colonies, particularly in specific culture conditions.
The functioning of the human cornea heavily relies on the maintenance of its extracellular matrix (ECM) mechanical properties. Within this context, corneal stromal fibroblasts (CSFs) are essential, as they are responsible for remodeling the corneal ECM. In this study, we used a decellularized human amniotic membrane (dHAM) and a custom fibrillar collagen film (FCF) to explore the effects of fibrillar materials on human CSFs.
View Article and Find Full Text PDFThe ability of human pluripotent stem cells for unlimited proliferation and self-renewal promotes their application in the fields of regenerative medicine. The morphological assessment of growing colonies and cells, as a non-invasive method, allows the best clones for further clinical applications to be safely selected. For this purpose, we analyzed seven morphological parameters of both colonies and cells extracted from the phase-contrast images of human embryonic stem cell line H9, control human induced pluripotent stem cell (hiPSC) line AD3, and hiPSC line HPCASRi002-A (CaSR) in various passages during their growth for 120 h.
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