Publications by authors named "Alina Riedel"
Article Synopsis
- Abnormal placental blood vessel development caused by high levels of anti-angiogenic factors like sFLT1 is associated with preeclampsia, a serious condition that affects pregnant women and their babies after 20 weeks.
- Previous studies on mice showed that increased hsFLT1 leads to reduced placental function and symptoms similar to preeclampsia.
- This research found elevated levels of the protein galectin-1 in specific areas of the placenta in hsFLT1 mice, suggesting that the galectin-glycan network may help counteract the harmful effects of anti-angiogenic factors during pregnancy.
Preeclampsia (PE) is characterized by maternal hypertension and placental dysfunction, often leading to fetal growth restriction (FGR). It is associated with an overexpression of the anti-angiogenic sFLT1 protein, which originates from the placenta and serves as a clinical biomarker to predict PE. To analyze the impact of sFLT1 on placental function and fetal growth, we generated transgenic mice with placenta-specific human sFLT1 (hsFLT1) overexpression.
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- - The placenta is crucial for fetal growth as it connects the embryo to the mother and significantly boosts blood flow through remodeled maternal spiral arteries.
- - Inadequate remodeling of these arteries can cause serious pregnancy issues like pre-eclampsia, primarily due to insufficient trophoblast invasion, with the exact processes still not fully understood.
- - A new study utilizes light sheet microscopy for 3D visualization of placental vascularization, offering a better understanding of spiral artery remodeling and paving the way for enhanced treatment insights related to pre-eclampsia.
Article Synopsis
- Fetal adaptations to pregnancy complications like preeclampsia (PE) can disrupt offspring metabolism, leading to lasting metabolic issues.
- Overexpression of sFLT1 in mice mimics PE, resulting in growth-restricted fetuses with reduced liver size, altered glycogen storage, and liver damage.
- Male offspring showed more severe metabolic alterations post-birth, including increased weight gain and changes in hormone levels, indicating that PE may cause specific metabolic disturbances that affect males more significantly.