Iminoglutamic succinic acid: assessment of the degree of biodegradation and toxicity of half-decomposition products.

Chelating agents used in agriculture and land reclamation practices must exhibit the capacity to firmly bind metal ions while also rapidly decomposing into non-toxic compounds due to their introduction into the environment in substantial quantities. It is therefore crucial to identify an alternative to EDTA, a prevalent chelating agent known for its low biodegradability and relatively high toxicity. This study focuses on assessing the degree of biodegradation of iminoglutamic succinic acid (IGSA) and the toxicity of its half-decomposition products.

Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasma.

Background And Objectives: COVID-19 convalescent plasma is an experimental treatment against SARS-CoV-2. The aim of this study is to assess the impact of different pathogen reduction methods on the levels and virus neutralizing activity of the specific antibodies against SARS-CoV2 in convalescent plasma.

Materials And Methods: A total of 140 plasma doses collected by plasmapheresis from COVID-19 convalescent donors were subjected to pathogen reduction by three methods: methylene blue (M)/visible light, riboflavin (R)/UVB and amotosalen (A)/UVA.