Publications by authors named "Alina Motygullina"
Article Synopsis
- Zinc is essential for life, but the mechanisms by which prokaryotes, like bacteria, selectively acquire it are not well understood, particularly in the protein AdcA.
- The study reveals that the N-terminal domain of AdcA is crucial for zinc import and utilizes a "trap-door" mechanism to effectively bind and transport zinc ions while making minimal changes in the protein's overall structure.
- This research enhances our understanding of zinc uptake in bacteria, which could inform new antimicrobial strategies to inhibit bacterial zinc acquisition by targeting the dynamic elements of the AdcA protein.
Non-uniform sampling (NUS) in combination with the Maximum Entropy (MaxEnt) algorithm as applied to multi-dimensional NMR data has been thoroughly investigated and the NUS approach shown to provide significant sensitivity improvements as compared to methods using uniformly sampled (US) data and the discrete Fourier transform (DFT). Hyperfine sublevel correlation (HYSCORE) is a standard pulse EPR experiment that can potentially benefit greatly from this approach, but the data present unique challenges as compared to NMR. HYSCORE data typically exhibit a very large range of peak intensities, signals are in the form of irregularly shaped ridges with variable intensities, and time traces are generally truncated to save measurement time.
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