Epidemiology of self-reported drug-induced immediate-type hypersensitivity reactions in the surgical population: a 5-year single-center survey in a romanian allergo-anaesthesia center.

Aim: Immediate-type hypersensitivity drug reactions are frequently under-reported, epidemiological data being imprecise. The aim of our study was to identify the drugs involved and to describe the clinical characteristics of previous immediate-type hypersensitivity reactions in a large series of Romanian surgical patients, and to establish the concordance between in vivo and in vitro tests.

Methods: Of the 807 surgical patients referred to our outpatient department of allergo-anaesthesia, we retrospectively enrolled 632 patients with previous drug-induced hypersensitivity reactions.