Effect of ultrasound amplitude and frequency on nanoparticle diffusion in an agarose hydrogel.

Exposure of nanoparticles in a porous medium, such as a hydrogel, to low-intensity ultrasound has been observed to dramatically enhance particle penetration rate. Enhancement of nanoparticle penetration is a key issue affecting applications such as biofilm mitigation and targeted drug delivery in human tissue. The current study used fluorescent imaging to obtain detailed experimental measurements of the effect of ultrasound amplitude and frequency on diffusion of nanoparticles of different diameters in an agarose hydrogel, which is often used as a simulant for biofilms and biological tissues.

Transition of a small Himalayan glacier lake outburst flood to a giant transborder flood and debris flow.

Glacial lake outburst floods (GLOFs) are a great concern for the Himalaya, as they can severely damage downstream populations and infrastructures. These floods originate at high altitudes and can flow down with enormous energy and change the terrain's existing morphology. One such devastating event occurred on the night of 5 July 2016, from the inconspicuous Gongbatongsha Lake, located in the Poiqu basin, Eastern Himalaya.

Sonoporation as an Approach for siRNA delivery into T cells.

Delivery of small interfering RNAs (siRNAs) into primary T cells is quite challenging because they are non-proliferating cells and are difficult to transfect with non-viral approaches. Because sonoporation is independent of the proliferation status of cells and siRNA acts in the cell cytoplasm, we investigated whether sonoporation could be used to deliver siRNA into mouse and human T cells. Cells mixed with Definity microbubbles and siRNA were sonicated with a non-focused transducer of center frequency 2.

Dermoscopic pattern of pityriasis versicolor.

Pityriasis versicolor (PV) is essentially a clinical diagnosis characterized by hypopigmented or hyperpigmented patches on the skin. Dermoscopy is gaining popularity as a noninvasive procedure for the diagnosis of different pigmentary and inflammatory disorders. However, scarce evidence exists on the dermoscopic pattern of PV.

Dermoscopic clues in the skin lesions of secondary syphilis.

Secondary syphilis may have a varied clinical presentation and might pose a diagnostic difficulty when a typical history is absent. We describe the dermoscopic clues of the skin lesions at different stages of the disease which could culminate to a proper diagnosis.

Tubular Hair Casts in Trichoscopy of Hair and Scalp Disorders.

Introduction: Hair casts have been reported in a variety of hair and scalp disorders. Trichoscopy allows a quick and noninvasive method for the evaluation of hair and scalp disorders in high magnification. However, the study of hair casts seen in trichoscopy is lacking.

Diagnosis of Woolly Hair Using Trichoscopy.

Hair shaft abnormalities including woolly hair are traditionally diagnosed by clinical examination and light microscopy which involves plucking of multiple hairs for examination. This is usually an inconvenient procedure especially in children. Trichoscopy may be a useful tool allowing close visualization of multiple hairs without causing discomfort to the patients.

Isolated lichen planus of lip: Diagnosis and treatment monitoring using dermoscopy.

Lichen planus (LP) of lip has chances of malignant transformation as it may be exposed to external trauma, smoking, and ultraviolet light. This case highlights the use of dermoscope as a quick noninvasive tool for the diagnosis of LP of lip and monitoring the response to treatment.