The effect of new non-cross resistant antitumour agents on the energy state of human erythrocytes.

Multidrug resistance (MDR) of tumour cells is related to the overexpression of ATP-dependent pumps responsible for the active efflux of antitumour agents out of resistant cells. Benzoperimidine and anthrapyridone compounds exhibit comparable cytotoxic activity against sensitive and MDR tumour cells. They diffuse extremely rapidly across the plasma membrane and render the ATP-dependent efflux inefficient.

Effect of lead ions on rat erythrocyte purine content.

The influence of short-term exposure to lead on the energetic status of erythrocytes in rats is reported in this study. The male Wistar rats selected for this study drank water containing 1% lead(II) acetate and/or intraperitoneal injections of 1 or 2 mg/kg body wt every 4 d starting on the eighth of the experiment, over a period of 1 mo. The whole-blood lead concentration measured after 4 wk was 1.

The effect of lead ions on the energy metabolism of human erythrocytes in vitro.

The aim of this work was to evaluate the influence of chronic exposure to lead ions on the parameters of energetic status of human erythrocytes in vitro. Umbilical cord erythrocytes were incubated with lead acetate at final lead ion concentrations ranging from 10 to 200 microg/dl. ATP, ADP, AMP, adenosine, GTP, GDP, GMP, guanosine, IMP, inosine, hypoxanthine, NAD and NADP concentrations in erythrocytes were determined using HPLC.