Publications by authors named "Alina Ioana Halip"
The thymus is a lymphoid organ involved in the differentiation of T cells, and has a central role in the physiopathogenesis of Myasthenia Gravis (MG). This connection is proved by a series of changes in the level of neuromuscular junctions, which leads to a decrease in the amplitude of the action potential in the post-synaptic membrane. Because of this, the presence of anti-cholinergic receptor antibodies (AChR), characteristic of MG, is found, which causes the progressive regression of the effect of acetylcholine at the level of neuromuscular junctions, with the appearance of muscle weakness.
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- Systemic sclerosis (SSc) is an autoimmune disorder characterized by excessive collagen buildup in the skin and organs, often linked to high levels of antinuclear antibodies (ANAs), though some cases show normal ANA levels, challenging previous assumptions.
- Many patients with negative ANAs in the study did not have any associated cancers, suggesting the need for more nuanced classifications of SSc.
- The research found a stronger correlation between specific autoantibodies and disease subsets compared to previous studies, highlighting the potential for more extensive research on SSc's immunological profiles.
Systemic sclerosis (SSc) is a relatively rare autoimmune disease with skin and visceral involvement, having a yet unknown etiopathogenesis. Research has shown that professional exposure to various polluting chemicals such as dyes, aliphatic and aromatic organic solvents, inhalable silica dust or certain heavy metals, can be triggering factors for this disease when they overlap a predisposing genetic profile. Smoking is still a debated factor involved in the etiology of SSc, as authors have divergent opinions on this matter.
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