External Validation of the Predictive Accuracy of Clinical and Immunological Scores in COVID-19 Outcomes in a Retrospective Cohort Study.

Background And Objectives: The COVID-19 pandemic has necessitated the development of reliable prognostic tools to predict patient outcomes and guide clinical decisions. This study evaluates the predictive utility of several clinical scores-PAINT, ISARIC4C, CHIS, COVID-GRAM, SOFA, and CURB-65-for in-hospital mortality among COVID-19 patients, comparing their effectiveness at admission and seven days post-symptom onset.

Methods: In this retrospective cohort study conducted at the Clinical Emergency Hospital Pius Brînzeu in Timișoara, adult patients hospitalized with confirmed SARS-CoV-2 infection were included.

Assessing the Utility of Prediction Scores PAINT, ISARIC4C, CHIS, and COVID-GRAM at Admission and Seven Days after Symptom Onset for COVID-19 Mortality.

The COVID-19 pandemic underscores the need for accurate prognostic tools to predict patient outcomes. This study evaluates the effectiveness of four prominent COVID-19 prediction scores-PAINT, ISARIC4C, CHIS, and COVID-GRAM-at two critical time points: at admission and seven days post-symptom onset, to assess their utility in predicting mortality among hospitalized patients. Conducted at the Clinical Emergency Hospital Pius Brînzeu in Timișoara, this retrospective analysis included adult patients hospitalized with confirmed SARS-CoV-2 infection.