The long noncoding RNA regulates myoblast plasticity and muscle regeneration through epithelial-mesenchymal transition.

Formation of skeletal muscle is among the most striking examples of cellular plasticity in animal tissue development, and while muscle progenitor cells are reprogrammed by epithelial-mesenchymal transition (EMT) to migrate during embryonic development, the regulation of EMT in post-natal myogenesis remains poorly understood. Here, we demonstrate that the long noncoding RNA (lncRNA) regulates EMT in myoblast differentiation and skeletal muscle regeneration. Chronic inhibition of in C2C12 myoblasts induced EMT, and suppressed cell state transitions required for differentiation.