HMOX1 Genetic Polymorphisms Display Ancestral Diversity and May Be Linked to Hypertensive Disorders in Pregnancy.

Racial disparity exists for hypertensive disorders in pregnancy (HDP), which leads to disparate morbidity and mortality worldwide. The enzyme heme oxygenase-1 (HO-1) is encoded by HMOX1, which has genetic polymorphisms in its regulatory region that impact its expression and activity and have been associated with various diseases. However, studies of these genetic variants in HDP have been limited.

Patient journey during and after a pre-eclampsia-complicated pregnancy: a cross-sectional patient registry study.

Objectives: To gain insight into the patient journey through a pre-eclampsia-complicated pregnancy.

Design: Cross-sectional patient registry study.

Setting: Online patient registry initiated by the Preeclampsia Foundation.

Patient-reported preconceptional characteristics in the prediction of recurrent preeclampsia.

Objective: To develop a prediction model for recurrent preeclampsia using patient-reported preconceptional characteristics, which can be used for risk stratification of subsequent pregnancies.

Study Design: Retrospective cohort study using data from The Preeclampsia Registry™ of 1028 women with a history of preeclampsia and at least one subsequent pregnancy.

Main Outcome Measures: Candidate predictors were included in a multivariable logistic regression analysis and a backward selection procedure was used to select the final predictors.

Information needs and experiences from pregnancies complicated by hypertensive disorders: a qualitative analysis of narrative responses.

Background: Incorporation of the patient voice is urgently needed in a broad array of health care settings, but it is particularly lacking in the obstetrical literature. Systematically derived information about patients' experience with hypertensive disorders of pregnancy (HDP), most notably preeclampsia, is necessary to improve patient-provider communication and ultimately inform patient-centered care and research. We sought to examine the information needs and experiences of individuals with pregnancies complicated by hypertensive disorders.

Women's attitudes, beliefs and values about tests, and management for hypertensive disorders of pregnancy.

Background: Advances in research suggest the possibility of improving routine clinical care for preeclampsia using screening (predictive) and diagnostic tests. The views of women should be incorporated into the way in which such tests are used. Therefore, we explored the views of women with experience of preeclampsia and other hypertensive disorders in pregnancy (HDPs) about predictive and diagnostic tests, treatment risks, and expectant management.

Cardiomyopathy and Preeclampsia.

Background: Preeclampsia is associated with diastolic dysfunction, peripartum cardiomyopathy, and both pre-existing and subsequent maternal cardiovascular disease. Gene mutations causing idiopathic cardiomyopathy were recently implicated in peripartum cardiomyopathy. We sought to determine whether cardiomyopathy gene mutations are also a contributory factor in preeclampsia.