Publications by authors named "Alina Boraman"
Nat Commun
September 2024
Article Synopsis
- Autophagy is a vital process that helps cells break down and recycle their components, with the final step being the degradation of autophagic cargo in lysosomes.*
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- Researchers used CRISPR/Cas9 technology to identify RNAseK as a crucial transmembrane protein that regulates the degradation of autophagosomes in cells, specifically affecting cargo breakdown while leaving other lysosomal functions intact.*
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- The study found that without RNAseK, the levels of certain hydrolases decrease, and there is an accumulation of VPS4a, indicating a disruption in the delivery pathway necessary for lysosomal degradation.*
