Publications by authors named "Alina Baiju"
Article Synopsis
- Rare inherited diseases caused by mutations in copper transporters (CTR1) lead to copper deficiency, which can cause severe neurological issues like seizures and neurodegeneration in infants.
- The study explores how neuronal cells react to copper deficiency using various genetic model systems, showing that the absence of CTR1 leads to disrupted cellular functions and a shift toward glycolysis.
- Key findings reveal that the activation of the mTORC1-S6K signaling pathway serves as a protective mechanism to enhance protein synthesis in response to copper deficiency, helping to mitigate some of the detrimental effects on neurons.
