Publications by authors named "Alina A Dzhaparova"
Article Synopsis
- The K98 capsular polysaccharide (CPS) from Acinetobacter baumannii clinical isolate REV-1184 was analyzed using various techniques, revealing its linear structure of tetrasaccharide repeats called K-units.
- These K-units consist of four unique sugar residues, including d-GlcpNAc and d-GalpNAc, with the latter modified by a pyruvic acid acetal group.
- Although K98 shares a similar composition with A. baumannii K4, the K98 CPS is linear while K4 is branched, attributed to differences in the Wzy polymerases responsible for their respective biosynthesis.
Whole genome sequences of two clinical isolates, 48-1789 and MAR24, revealed that they carry the KL106 and KL112 capsular polysaccharide (CPS) biosynthesis gene clusters, respectively, at the chromosomal K locus. The KL106 and KL112 gene clusters are related to the previously described KL11 and KL83 gene clusters, sharing genes for the synthesis of l-rhamnose (l-Rha) and 6-deoxy-l-talose (l-6dTal). CPS material isolated from 48-1789 and MAR24 was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy.
View Article and Find Full Text PDF