Photoluminescence imaging of single photon emitters within nanoscale strain profiles in monolayer WSe.

Local deformation of atomically thin van der Waals materials provides a powerful approach to create site-controlled chip-compatible single-photon emitters (SPEs). However, the microscopic mechanisms underlying the formation of such strain-induced SPEs are still not fully clear, which hinders further efforts in their deterministic integration with nanophotonic structures for developing practical on-chip sources of quantum light. Here we investigate SPEs with single-photon purity up to 98% created in monolayer WSe via nanoindentation.

[New possibilities in antibacterial treatment of intra-abdominal infections caused by multiresistant microflora].

Aim: To determine the place of new drugs with activity against multidrug resistant strains of microorganisms in the treatment of complicated intraabdominal infections.

Material And Methods: The incidence and distribution of pathogens isolated from intra-abdominal specimens in patients with intra-abdominal infections are analyzed.

Results: The current situation on the growth of resistant strains among pathogens causing intra-abdominal infections is rewied.

Partial clinical response to anakinra in severe palmoplantar pustular psoriasis.

Background: Palmoplantar pustular psoriasis is a clinical psoriasis variant characterised by a high impact on quality of life and poor response to biologics approved for plaque type psoriasis.The recombinant interleukin-1 (IL-1) receptor antagonist anakinra has been recently used for the treatment of isolated refractory cases of generalised pustular psoriasis with contrasted results.

Objectives: To report the clinical response in two patients treated with anakinra as salvage therapy in two patients with severe palmoplantar pustular psoriasis refractory to currently available antipsoriatic systemic therapies.

[Relapsing annular erythema following streptococcal throat infection in an adult patient: Adult erythema marginatum associated with rheumatic fever].

Background: Erythema marginatum is one of the main Jones diagnostic criteria for rheumatic fever. However, since it rarely occurs in industrialized countries, this diagnosis is seldom suspected, especially in adult patients.

Case Report: We report a case of an annular facial eruption associated with fever and polyarthralgia seen twice in a 30-year-old woman following episodes of streptococcal throat infection.

[Selection of therapy with nitrates in patients with stable effort angina: results of comparative study of common isosorbide dinitrate and long acting preparation of isosorbide-5-mononitrate].

Aim: To assess efficacy and tolerability of a novel drug form of isosorbide-5-mononitrate in patients with ischemic heart disease and stable effort angina as compared with common isosorbide dinitrate pills.

Material And Methods: Patients with stable class II-III effort angina (n=30) were included into a randomized crossover study in which they received isosorbide dinitrate (nitrosorbide, 10-20 mg t.i.

[Effects of long-acting calcium antagonists--amlodipine and diltiazem in patients with stable angina of effort: comparative randomized controlled trial].

Aim: To compare effectiveness of two long-acting calcium antagonists--amlodipin and diltiazem--in patients with ischemic heart disease (IHD) and stable angina of effort (SAE).

Material And Methods: 31 IHD patients with SAE entered the double blind randomized trial. The patients received either amlodipin (5-10 mg once a day) or diltiazem (120-180 mg twice a day) for 4 weeks.

[Comparison of carvedilol and atenolol efficacy in patients with stable effort angina].

Aim: To compare effectiveness of carvedilol--beta-adrenoblocker with vasodilating action--with atenolol which is beta-adrenoblocker having no vasodilating activity in coronary heart disease (CHD) patients with stable effort angina.

Material And Methods: The trial entered 28 CHD patients with a history of myocardial infarction (MI). All the patients had no contraindications to beta-adrenoblockers, had positive exercise tolerance test.

[Comparative study of spirapril (quadropril) and amlodipine efficacy. Results of randomized trial in patients with mild to moderate arterial hypertension].

Aim: To compare in the non-blind randomised parallel study the efficiency of quadropril and amlodipine in the treatment of mild to moderate arterial hypertension.

Material And Methods: A total of 80 patients (57.6 +/- 1.

[Spirapril - a new long-acting ACE inhibitor: efficacy and safety in patients with arterial hypertension in combination with diabetes mellitus and impaired kidney function].

Aim: To examine effectiveness and safety of quadropril.

Material And Methods: Changes in blood pressure (BP), heart rate (HR), levels of glucose, potassium and creatinine, creatinine clearance were studied in 120 patients (48 males and 72 females, mean age 60.6 +/- 0.

[The calcium antagonists diltiazem and nifedipine: a comparison of their efficacy in single and long-term use in patients with stable stenocardia of effort].

Aim: To compare efficacy of diltiazem and nifedipine in single dose and long-term treatment.

Materials And Methods: A randomised double-blind cross-over study enrolled 17 patients suffering from coronary heart disease (CHD) with stable angina of effort (SAE). For 1 month, each patient received diltiazem and nifedipine (60-90 mg 4 times a day and 20-30 mg 4 times a day, respectively).

[Molsidomine and isosorbide dinitrate: a comparative trial of tolerance in long-term intake by IHD patients with stable angina of effort].

Potential tolerance to isosorbide dinitrate (ID) and molsidomine (M) was studied in 18 ischemic heart disease (IHD) patients with stable angina of effort entered in a double blind cross-over trial. Each drug was administered for 3 weeks 4 times a day in individual effective dose. Single doses of ID and M were similar by effectiveness, but after 3 weeks of regular intake their efficacy fell, ID becoming less potent than M.

[The clinical and computed tomographic criteria of the diagnosis of multiple systemic cerebral atrophy with progressive autonomic insufficiency (the Shy-Drager syndrome)].

Based on clinical and CT examination of 3 patients with Shy-Drager syndrome and the reported data, differential diagnosis of the given diseases is under discussion. Shy-Drager syndrome is characterized by CT signs of progressive atrophy of the pons and cerebellum with no essential changes in the supratentorial brain structures. The authors support a proposal to use the term "multiple systemic atrophy" for designation of the disease entity that includes both Shy-Drager syndrome and sporadic patterns of olivopontocerebellar and strionigral degenerations in which the disease debuts by motor disorders of the extrapyramidal and cerebellar nature rather than by vegetative disturbances.

[Autonomic disorders in parkinsonism].

The authors analyze the clinical and paraclinical manifestations of vegetative disorders in parkinsonism. It is shown that vegetative disorders are relatively independent of motor parkinsonism manifestations and run their course by the type of concomitant sympathetic and parasympathetic insufficiency. Injury to the segmental and suprasegmental mechanisms of motor control underlies vegetative disorders.

[Cardiovascular tests in various forms of pathology].

Quantitative estimation of the status of the autonomic nervous system is a research priority in neurology. One of the approaches to its solving lies in the use of cardiovascular tests. The authors brief the mechanisms of the tests, provide their standards.

[The concept of "ganglionitis" in the modern science of the autonomic nervous system].

The authors review the concept of vegetative "ganglionitis" formed in the Soviet literature in the 40-60s. Consider the etiological, clinical and diagnostic aspects thereof. Provide the modern concepts of the clinical manifestations related to the lesions of the paravertebral sympathetic ganglia.

[Primary generalized amyloidosis with the progressive autonomic insufficiency syndrome].

The paper is concerned with a case of primary generalized amyloidosis characterized by the presence of a well-defined syndrome of progressive vegetative failure within the framework of neurologic complications of amyloidosis.

[Autonomic disorders in Parkinson disease].

The authors provide the clinical and laboratory findings regarding the vegetative nervous system in 60 patients with parkinsonism and in 11 healthy volunteers. It has been found that parkinsonism is necessarily associated with vegetative disorders which are pronounced to a greater degree in right-handed patients and bilateral clinical manifestations of the syndrome.

[Metabolism of fatty acids with an odd number of carbon atoms].

The paper is concerned with main results of investigations and data available in literature on the metabolism of higher odd-numbered fatty acids significant for elucidating the role of these acids in the animal organism at the neo- and postnatal developmental stages. Special attention is paid to the relation between the metabolism of fatty acids, propionate and phospholipids. Labelled 14C from [2- 14C] propionate is shown to incorporate into choline of the liver and brain phospholipids of the rats aged 21 days (the period of intensive myelinization).

[Lipid composition of erythrocyte membranes and blood serum in meningococcal infections in children].

Significant impairments of lipid homeostasis were observed in lipid composition of erythrocyte membranes and blood serum in acute period of meningococcal infection, involving pronounced alterations in content of phospholipids, phospholipid fractions, total cholesterol, unesterified fatty acids as well as activation of phospholipase A2. The degree and pattern of dyslipidemia depended on clinical form, severity of the disease and age of children. The most serious deteriorations were found in the patients with a mixed form of the disease, at early age and during the critical period of meningitis.