β-Thalassemia intermedia: a comprehensive overview and novel approaches.

β-Thalassemia intermedia is a clinical condition of intermediate gravity between β-thalassemia minor, the asymptomatic carrier, and β-thalassemia major, the transfusion-dependent severe anemia. It is characterized by a significant clinical polymorphism, which is attributable to its genetic heterogeneity. Ineffective erythropoiesis, chronic anemia, and iron overload contribute to the clinical complications of thalassemia intermedia through stepwise pathophysiological mechanisms.

[The serum erythropoietin under intermediate B-thalassemia].

The study explored the level of serum erythropoietin in patients with intermediate beta-thalassemia to determine possible correlations with hemoglobin level and fetal hemoglobin level and other parameters. The sampling consisted of 58 examined patients with intermediate beta-thalassemia. The contrl group consisted of 30 healthy persons.