Publications by authors named "Alim A O Bashirzade"
Article Synopsis
- The zebrafish is a valuable model for biomedical research, particularly in studying neurotoxicity and testing drugs for neuroactive effects.
- This study focused on MPTP, a chemical that causes neuron degeneration and is used to simulate Parkinson's disease in lab experiments, to identify its impact on cognitive function in zebrafish.
- Researchers established a specific dosage for administering MPTP and discovered that it impaired spatial working memory in zebrafish, while also utilizing AI to analyze swimming behaviors, indicating that high doses of MPTP create noticeable behavioral changes in the fish.
Due to its fully sequenced genome, high genetic homology to humans, external fertilization, fast development, transparency of embryos, low cost and active reproduction, the zebrafish has become a novel promising model organism in biomedicine. Zebrafish are a useful tool in genetic and neuroscience research, including linking various genetic mutations to brain mechanisms using forward and reverse genetics. These approaches have produced novel models of rare genetic CNS disorders and common brain illnesses, such as addiction, aggression, anxiety and depression.
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