Publications by authors named "Aliki Grammatikaki"
Nat Cardiovasc Res
October 2024
Article Synopsis
- Evolutionary changes in RNA translation rates and new genes, including small open reading frames, play a key role in the development of innovations in primates and rodents.
- This study examined the hearts of four primate species and two rodent species using advanced ribosome and transcriptomic profiling techniques, focusing on adult heart tissues and stem cell-derived heart cells.
- Findings revealed rapid evolution in the translation efficiency of mitochondrial complexes and identified numerous unique genomic features related to primate heart evolution, highlighting mechanisms that influence cardiac development and potential disease.
