Publications by authors named "Alika Guseva"
Cardiosphere-derived cells (CDCs) are currently being evaluated in clinical trials as a potential therapeutic tool for regenerative medicine. The effectiveness of transplanted CDCs is largely attributed to their ability to release beneficial soluble factors to enhance therapeutic effects. An emerging area of research is the pretreatment of stem cells, including CDCs, with various cytokines to improve their therapeutic properties.
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- Ischemic heart disease is a leading cause of death, with the adult heart lacking natural regenerative abilities after damage.
- Stem-cell-based therapies, particularly cardiosphere-derived cells (CDCs), show promise for treating heart damage due to their ability to secrete bioactive molecules that promote healing.
- Research indicates that Tumor Necrosis Factor alpha (TNFa), present in the inflammatory environment of damaged heart tissue, can enhance the secretome of CDCs, potentially improving their ability to support new blood vessel formation.