[Retracted] Arctigenin, a natural lignan compound, induces G/G cell cycle arrest and apoptosis in human glioma cells.

[This retracts the article DOI: 10.3892/ol.2016.

Arctigenin, a natural lignan compound, induces G/G cell cycle arrest and apoptosis in human glioma cells.

The aim of the current study was to investigate the anticancer potential of arctigenin, a natural lignan compound, in malignant gliomas. The U87MG and T98G human glioma cell lines were treated with various concentrations of arctigenin for 48 h and the effects of arctigenin on the aggressive phenotypes of glioma cells were assessed. The results demonstrated that arctigenin dose-dependently inhibited the growth of U87MG and T98G cells, as determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and bromodeoxyuridine incorporation assays.