Transient elastography and diffusion-weighted magnetic resonance imaging for assessment of liver fibrosis in children with chronic hepatitis C.

Background: Chronic hepatitis C (CHC) is a health burden with consequent morbidity and mortality. Liver biopsy is the gold standard for evaluating fibrosis and assessing disease severity and prognostic purposes post-treatment. Noninvasive alternatives for liver biopsy such as transient elastography (TE) and diffusion-weighted magnetic resonance imaging (DW-MRI) are critical needs.

Generic sofosbuvir/ledipasvir for the treatment of genotype 4 chronic hepatitis C in Egyptian children (9-12 years) and adolescents.

Background/purpose Of The Study: Worldwide and national efforts are directed against eradication of HCV. The introduction of direct-acting antivirals (DAAs) has changed dramatically the outcome of HCV treatment. In spite of the Food and Drug Administration approval of the oral drugs sofosbuvir (SOF) and ledipasvir (LED) for the treatment of HCV in adolescents more than or equal to 12 years old, sufficient real-world experience is still lacking.

Design and validation of a diagnostic score for biliary atresia.

Background & Aims: The dilemma of early diagnosis of biliary Atresia (BA), particularly distinguishing it from other causes of neonatal cholestasis is challenging. The aim was to design and validate a scoring system for early discrimination of BA from other causes of neonatal cholestasis.

Methods: A twelve-point scoring system was proposed according to clinical, laboratory, ultrasonographic, and histopathological parameters.

Lipocalin-2 as a marker of bacterial infections in chronic liver disease: a study in Egyptian children.

Bacterial infections are common in chronic liver disease, and may precipitate other complications, such as encephalopathy and hepatorenal syndrome. The physiologic functions of lipocalin-2 remain poorly understood. Our aim was to elucidate lipocalin-2 as a useful marker of bacterial infections in children with CLD.