Melatonin Aids in Treating Mood and Sleep Problems Resulting from Hormonal Therapy in Breast Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial.

Background: Hormone therapy is commonly used to treat breast cancer but can cause mood disorders and sleep disturbances, negatively impacting patients' well-being.

Objectives: This trial aimed to evaluate the effects of melatonin on sleep problems and mood changes in breast cancer patients undergoing hormone therapy.

Methods: The study was conducted at Omid Hospital in Isfahan, Iran, using a randomized, double-blinded, placebo-controlled design.

The role of miR-16 and miR-34a family in the regulation of cancers: A review.

microRNAs (miRNAs), regulatory non-coding RNAs, can change translation, and decrease protein expression. miR-16 and miR-34a families are among the most abundant tumor suppressors and highly conserved microRNAs recognized. They have vital regulatory roles in health and disease.

Does structural compromise of the aorta in patients with aortic pathologies predict increased spinal and vascular complications and reoperations in patients undergoing anterior approach to the spine?

Objectives: Anterior spinal fusion (ASF) presents unique challenges, including the proximity of critical anatomic structures. Previous reports have detailed vascular injuries during exposure/approach; however, it is not well-documented whether structural aortic pathology, such as aneurysm, dissection, atherosclerosis, aortitis, or aortic tumors, impacts postoperative outcomes following anterior approach to the spine for spinal fusion.

Materials And Methods: Using the New York State Statewide Planning and Research Cooperative System, thoracolumbar ASF patients with a history of aneurysm, dissection, atherosclerosis, aortitis, or aortic tumors (APath) were identified and matched to patients with no aortic pathologies (No-APath).

Multivariate Gaussian Bayes classifier with limited data for segmentation of clean and contaminated regions in the small bowel capsule endoscopy images.

A considerable amount of undesirable factors in the wireless capsule endoscopy (WCE) procedure hinder the proper visualization of the small bowel and take gastroenterologists more time to review. Objective quantitative assessment of different bowel preparation paradigms and saving the physician reviewing time motivated us to present an automatic low-cost statistical model for automatically segmenting of clean and contaminated regions in the WCE images. In the model construction phase, only 20 manually pixel-labeled images have been used from the normal and reduced mucosal view classes of the Kvasir capsule endoscopy dataset.

Oxidative stress markers in occupational noise exposure: a systematic review and meta-analysis.

Background: Exposure to occupational noise could lead to detrimental health outcomes by inducing oxidative stress mechanisms. In this study, we sought to investigate the impact of occupational noise exposure on serum and/or plasma levels of oxidative stress markers.

Methods: We performed a thorough search across PubMed, Web of Science, and SCOPUS for articles comparing oxidative stress markers, including malondialdehyde (MDA) and/or superoxide dismutase (SOD) and/or glutathione peroxidase (GPx) and/or total antioxidant capacity (TAC), in individuals occupationally exposed to high noise and unexposed controls.

Lymphoscintigraphy for Peri-Anal Squamous Cell Carcinoma: A Case Report of an Atypical Location for Sentinel Lymph Node.

This case report describes a 41-year-old man with a progressively enlarging, painful vegetative lesion in the perianal region, ultimately diagnosed as squamous cell carcinoma (SCC), through a punch biopsy. Sentinel lymph node (SLN) mapping was performed via preoperative lymphoscintigraphy utilizing 99mTc-Phytate. Notably, an SLN was identified in an atypical location, below the anterior superior iliac spine (ASIS) in the subcutaneous tissue, diverging from typical drainage patterns associated with perianal SCC.

Exploring facilitators and barriers faced by PhD nursing faculty in clinical settings: a qualitative content analysis.

Background: Most nurses with PhDs typically work in academic settings, although some remain in clinical settings. Little is known about the support systems and challenges they encounter in these clinical environments. The objective of this study was to comprehensively investigate and gain valuable insights into the experiences of nursing faculties in clinical settings, focusing specifically on the factors that facilitate or hinder their work and professional development.

EphB4-ephrin-B2 are targets in castration resistant prostate cancer.

Background: PI3K pathway activation is a common and early event in prostate cancer, from loss of function mutations in PTEN, or activating mutations in PIK3Ca or AKT leading to constitutive activation, induction of growth factor-receptors kinase EphB4 and its ligand ephrin-B2. We hypothesized that induction of EphB4 is an early event required for tumor initiation. Secondly, we hypothesized that EphB4 remains relevant when prostate cancer becomes androgen independent.

Corrigendum: Construction of a circRNA-lincRNA-lncRNA-miRNA-mRNA ceRNA regulatory network identifies genes and pathways linked to goat fertility.

[This corrects the article DOI: 10.3389/fgene.2023.

Climate change's impact on the nervous system: A review study.

Background: Global warming is caused by increased carbon dioxide and other industrial gases, which shift the climate of human habitat and environment, impacting human health globally. In this review, we tried to overview the current knowledge of climate change's impact on neurological disease.

Methods: A comprehensive search on PubMed, Web of Science (WOS), and Scopus was conducted to find the relevant original studies.

Recent advances in the clinical management of intoxication by five heavy metals: Mercury, lead, chromium, cadmium and arsenic.

Metals have been used for many centuries, but their nutritional and toxic effects have been investigated since the last century. The common toxic heavy metals (THM) include mercury, lead, chromium cadmium, and arsenic. As human exposure to THM increasingly causes systemic and organ complications, it seems required to review the recent advances of treatment of the toxic metals.

Predicting Diabetes in Canadian Adults Using Machine Learning.

Rising diabetes rates have led to increased healthcare costs and health complications. An estimated half of diabetes cases remain undiagnosed. Early and accurate diagnosis is crucial to mitigate disease progression and associated risks.

Nursing students' compassion competence: impact of emotional intelligence and fear of compassion in a cross-sectional study.

Background: Compassion is an important competence for nursing students, and it is essential to identify factors that affect it, such as emotional intelligence and fear of compassion. The purpose of this study was to examine the levels of emotional intelligence, fear of compassion, and compassion competence and their association among nursing students.

Methods: A cross-sectional correlational study was carried out in the faculty of nursing and midwifery, Hamadan University of Medical Sciences in Iran.

Echocardiographic Characterization of Myocardial Stiffness in Healthy Volunteers, Cardiac Amyloidosis, and Hypertrophic Cardiomyopathy: A Case-Control Study Using Multimodality Imaging.

Background: Noninvasive tools to measure myocardial stiffness are limited. Intrinsic cardiac elastography in echocardiography relates to myocardial stiffness by measuring the propagation of the myocardial stretch generated by atrial contraction. The aims of the present study were (1) to evaluate myocardial stiffness using intrinsic cardiac elastography in healthy volunteers versus those with myocardial diseases (ie, cardiac amyloidosis [CA] and hypertrophic cardiomyopathy) and (2) to identify key factors that affect myocardial stiffness.

Top-Down Proteomic Profiling of Protein Corona by High-Throughput Capillary Isoelectric Focusing-Mass Spectrometry.

In the rapidly evolving field of nanomedicine, understanding the interactions between nanoparticles (NPs) and biological systems is crucial. A pivotal aspect of these interactions is the formation of a protein corona when NPs are exposed to biological fluids (e.g.

Global and regional incidence of intrahepatic cholestasis of pregnancy: a systematic review and meta-analysis.

Background: Intrahepatic cholestasis of pregnancy (ICP) can be a source of significant distress for both pregnant women and the fetus, impairing the quality of life and well-being of pregnant women, leading to psychological disorders among pregnant women with severe or recurrent ICP, and causing life-threatening complications among fetuses. Regrettably, our current understanding of ICP globally is limited, lacking a comprehensive estimation of its incidence. Therefore, in this systematic review and meta-analysis, we aimed to investigate the global and regional incidence of ICP and identify factors that account for its variety across studies.

The complex interplay: How lifestyle and psychosocial factors contribute to hypertension in myocardial infarction patients-An integrated model.

Introduction: A significant proportion of acute myocardial infarction (MI) patients also suffer from hypertension (HTN), underscoring the need for effective HTN prevention and management strategies in this group. This study aims to elucidate the complex web of direct and indirect factors contributing to HTN in the context of MI.

Material And Methods: The study utilized longitudinal data from patients aged 18-75 experiencing their first ST-segment elevation MI from five major provinces of Iran, including Tehran, Isfahan, Yazd, Gilan, and Hormozgan.

Validation of a Cross-Cultural Adaptation of the M.D. Anderson Dysphagia Inventory to Canadian French (MDADI-CF).

The MDADI is a validated tool for assessing quality of life in several languages, often used for patients with head and neck cancer (HNC). It has never been translated and validated in Canadian French, which bears significantly different linguistic characteristics compared to European French. Our objective was to validate a Canadian French version of the MDADI (MDADI-CF) for HNC patients suffering from dysphagia.

A preliminary study of the association between and quantification of selected yeasts in IBD and IBS patients.

Objective: Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) are gastrointestinal disorders, which can be triggered by gut microbiota dysbiosis. The development of IBS-like symptoms has been linked to the overgrowth of spp. In addition, the critical role of fungi has been highlighted in the pathogenesis of IBD.

Radiotracer Accumulation in the Pyelocaliceal System of Transplanted Kidney: A Potential Pitfall in Lymphoscintigraphy of Pelvic Malignancies.

A 34-year-old woman with a history of renal transplantation and cervical cancer underwent lymphoscintigraphy using 99mTc-phytate before surgery. Initial planar images revealed multiple foci of uptake, which were later precisely localized using SPECT/CT imaging. Notably, uptakes in the right lower quadrant were attributed to the pyelocalyceal system of the transplanted kidney, highlighting a potential pitfall in patients with ectopic or transplanted kidneys.

The efficacy of DASH combined with time-restricted feeding (16/8) on metabolic associated fatty liver disease management: a randomized controlled trial.

Recent studies have utilized time-restricted feeding (16/8) (TRF) and dietary approaches to stop hypertension separately to manage metabolic-associated fatty liver disease (MAFLD); however, the effectiveness of combining these two approaches has not been investigated. The objective of this study was to examine the impact of TRF in conjunction with a DASH diet on various factors related to MAFLD. A 12-week randomized controlled trial was conducted to assess the impact of TRF (16/8), along with a DASH diet, compared with a control diet based on standard meal distribution, in patients with MAFLD.

Dietary intake of tomato and lycopene, blood levels of lycopene, and risk of total and specific cancers in adults: a systematic review and dose-response meta-analysis of prospective cohort studies.

Background: The association between tomato/lycopene intake and blood levels of lycopene with the risk of specific cancers were assessed in previous meta-analyses; however, no study evaluated the risk of overall cancer incidence/mortality. Therefore, the present systematic review and dose-response meta-analysis aimed to summarize available findings from prospective studies to examine the association between tomato/lycopene intake and lycopene levels with the risk of total and specific cancers and cancer-related mortality.

Methods: A comprehensive literature search was done using Scopus, PubMed, ISI Web of Science, and Google Scholar until July 2023.