Publications by authors named "Alidoust L"
Article Synopsis
- * The results indicated that 84.8% of the isolates formed biofilms and had a higher prevalence of specific adhesin genes, while 52.4% of isolates produced extended-spectrum beta-lactamases (ESBL) and 84.8% were multidrug-resistant (MDR).
- * Hypertension was identified as a potential risk factor for infections caused by ESBL-producing UPEC, emphasizing the need for careful monitoring of antibiotic use and consideration of local risk factors
Article Synopsis
- Diabetic retinopathy (DR) is a common complication of diabetes, and the study aimed to explore the relationship between specific variants of the TCF7L2 gene and DR in Type 2 diabetes patients.
- The research involved analyzing DNA from 524 Type 2 diabetes patients, of which 290 had DR and 234 did not, using genetic testing methods and evaluating clinical characteristics.
- Results showed that, despite significant differences in clinical factors like blood sugar and family history of diabetes, the TCF7L2 gene variants did not show a significant association with DR in this Iranian population, suggesting possible different roles in other populations.
Background And Aim: Alzheimer's disease (AD), a prevalent progressive neurodegenerative disease, is mainly characterized by dementia, memory loss, and cognitive disorder. Rising research was performed to develop pharmacological or non-pharmacological approaches to treat or improve AD complications. Mesenchymal stem cells (MSCs) are stromal cells that can self-renew and exhibit multilineage differentiation.
View Article and Find Full Text PDFDiabetic Retinopathy (DR) is one of the most severe micro-vascular complications of diabetes mellitus (DM), involving interactions between environmental and genetic risk factors. KCNJ11 gene has a key role in insulin secretion and is of substantial interest in various populations. A population-based association of 524 T2DM patients was performed to delineate the genetic influence of KCNJ11 polymorphisms (rs5219, c.
View Article and Find Full Text PDFAmong seven strains of lactic acid bacteria (LAB) isolated from traditional dairy products, a Lactobacillus strain was identified through 16S rRNA gene sequencing and tentatively designated as Lactobacillus brevis MK05. This strain demonstrated the highest probiotic potential through biochemical analysis, including acid and bile salt resistance, as well as antibacterial activity. The collected cell-free supernatant (CFC) of L.
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- The study builds on previous research about Nostoc entophytum ISC32's response to cadmium-induced stress at cellular and molecular levels, focusing on changes in antioxidant enzyme activity and lipid peroxidation.
- Exposure to cadmium at lower concentrations (2 and 5 mg/L) significantly increased catalase and peroxidase activity, but higher concentrations (10 and 20 mg/L) did not yield substantial changes, and high cadmium levels caused notable lipid peroxidation after prolonged exposure.
- Structural analysis revealed significant alterations in the cyanobacterial cells, such as cell shrinkage and detachment of the mucilage layer due to cadmium toxicity, especially at concentrations above the minimum inhibitory concentration (30 mg/L), indicating a defense response
Among nine cyanobacterial strains isolated from oil-contaminated regions in southern Iran, an isolate with maximum cadmium uptake capacity was selected and identified on the basis of analysis of morphological criteria and 16S rRNA gene sequence similarity as Nostoc entophytum (with 99% similarity). The isolate was tentatively designated N. entophytum ISC32.
View Article and Find Full Text PDFThe present study was conducted to determine the potential of five cyanobacteria strains isolated from aquatic zones to induce lipid production. The phylogenetic affiliation of the isolates was determined by 16S rRNA gene sequencing. Amongst the isolates, an efficient cyanobacterium, Synechococcus sp.
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- Recent research highlights the growing interest in discovering new probiotic strains due to increased market demand, focusing on 15 Lactobacillus isolates from Iranian dairy products.
- A novel strain identified as Lactobacillus crustorum KH showed significant properties, including tolerance to acidity, bile, and salinity, along with notable antibacterial activity against harmful bacteria.
- In animal studies, both live and heat-killed L. crustorum KH were tested for their protective effects against E. coli O157:H7 in mice, with heat-killed cells offering some protection, though less effective than the live cells.
In the current study, different protein expression profiles in a strain Brevundimonas sp. ZF12, isolated from the aqueous zone containing high levels of radiation, were characterized following exposure to cadmium (II) using a proteomic strategy. In order to gain a deeper understanding of the cellular events that allow this strain to survive and undergo cadmium adaptation and sorption, the strain was tested under three experimental conditions of 5, 10 and 30 ppm cadmium (II) ions stress.
View Article and Find Full Text PDFA biosurfactant-producing thermophile was isolated from the Kahrizak landfill of Tehran and identified as a bacterium belonging to the genus Aneurinibacillus. A thermostable lipopeptide-type biosurfactant was purified from the culture medium of this bacterium and showed stability in the temperature range of 20-90 °C and pH range of 5-10. The produced biosurfactant could reduce the surface tension of water from 72 to 43 mN/m with a CMC of 1.
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