Publications by authors named "Alid Guadarrama-Martinez"
Oligoclonal mixtures of broadly-neutralizing antibodies can neutralize complex compositions of similar and dissimilar antigens, making them versatile tools for the treatment of e.g., infectious diseases and animal envenomations.
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- Each year, Mexico reports around 3,800 snakebite cases, leading to 35 deaths, with the primary treatment being antivenoms derived from horse antibodies against venom.
- This study evaluates the effectiveness of three different antivenoms against various pit viper venoms, demonstrating significant differences in their neutralizing abilities and highlighting the poor response to Crotalus atrox venom, a major cause of bites in the north.
- Results indicate that no antivenom could effectively neutralize the lethal effects of Metlapilcoatlus nummifer and Porthidium yucatanicum, suggesting a pressing need for the development of more effective treatments.
Within Neotropical pit-vipers, the Mexican/Central-American clade consisting of , , , and is a wide-ranging, morphologically and ecologically diverse group of snakes. Despite their prevalence, little is known of the functional aspects of their venoms. This study aimed to fill the knowledge gap regarding coagulotoxic effects and to examine the potential of different therapeutic approaches.
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