Publications by authors named "Alicja Maksymiuk"
The vertebrate body forms by the addition of new tissues at the posterior end. This elongates the body axis, allowing continued anterior segmentation to produce the stereotypic body plan. This balance requires the elongation speed to be constrained.
View Article and Find Full Text PDFThe novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused both a health and economic crisis around the world. Its papain-like protease (PLpro) is one of the protein targets utilized in designing new drugs that would aid vaccines in the fight against the virus. Although there are already several potential candidates for a good inhibitor of this protein, the degree of variability of the protein itself is not taken into account.
View Article and Find Full Text PDFArticle Synopsis
- SARS-CoV-2's papain-like protease (PLpro) is crucial for the virus's replication and can modify host proteins, making it a key target for antiviral drug development.
- The researchers conducted extensive in silico screening of 15 million compounds to find noncovalent inhibitors of PLpro, eventually identifying 387 potential candidates.
- The best 20 compounds demonstrated significant activity against PLpro with IC values in the nanomolar range, and six of these are recommended for further testing to evaluate their effectiveness against SARS-CoV-2.