Publications by authors named "Alicja Ewiak-Paszynska"
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) with a complex and not fully understood etiopathological background involving inflammatory and neurodegenerative processes. CHI3L1 has been implicated in pathological conditions such as inflammation, injury, and neurodegeneration, and is likely to play a role in the physiological development of the CNS. CHI3L1 is primarily produced by CNS macrophages, microglia, and activated astrocytes.
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- YKL-40 (CHI3L1) is a glycoprotein involved in inflammation and cancer, but its specific role in the body is not well understood.
- This study focused on how YKL-40 is expressed and secreted in HL-60 cells treated with DMSO, alongside measuring cell surface markers CD11b and CD66b during differentiation over 120 hours.
- The results showed a time-dependent increase in YKL-40 production and secretion linked to changes in cell differentiation, suggesting its potential involvement in physiological processes and diseases like multiple sclerosis.
NK cells (natural killer cells) being a part of the innate immune system have been shown to be involved in immunoregulation of autoimmune diseases. Previously we have shown that HINT1/Hsp70 treatment induced regulatory NK cells ameliorating experimental autoimmune encephalomyelitis (EAE) course and CD4+ T cells proliferation. NK cells were isolated from mice treated with HINT1/Hsp70 and co-cultured with proteolipid protein (PLP)-stimulated CD4+ T cells isolated from EAE mice.
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