Publications by authors named "Alicia Ruiz-Ripa"
Coagulopathy is a key feature of COVID-19 and D-dimer has been reported as a predictor of severity. However, because D-dimer test results vary considerably among assays, resolving harmonization issues is fundamental to translate findings into clinical practice. In this retrospective multicenter study (BIOCOVID study), we aimed to analyze the value of harmonized D-dimer levels upon admission for the prediction of in-hospital mortality in COVID-19 patients.
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- Myocardial injury, indicated by elevated cardiac troponin levels, is often found in COVID-19 patients and is linked to disease severity and 30-day mortality rates.
- In a study of 1280 hospitalized COVID-19 patients, 30% exhibited elevated troponin levels, with higher prevalence observed using sex-specific cut-offs, particularly for troponin T.
- Elevated troponin levels significantly predicted mortality risk, suggesting that early monitoring of these levels can help doctors assess the severity of COVID-19 in patients.
Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study).
Scand J Clin Lab Invest
May 2021
Identification of predictors for severe disease progression is key for risk stratification in COVID-19 patients. We aimed to describe the main characteristics and identify the early predictors for severe outcomes among hospitalized patients with COVID-19 in Spain. This was an observational, retrospective cohort study (BIOCOVID-Spain study) including COVID-19 patients admitted to 32 Spanish hospitals.
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- The research presents a new mouse model designed to study hepatitis delta virus (HDV) infection, which closely resembles human disease characteristics.
- Using adeno-associated viruses, scientists were able to successfully initiate HDV replication in mouse liver cells, evaluate immune responses, and observe liver damage linked to co-infection with hepatitis B virus (HBV).
- The study highlights the role of the mitochondrial antiviral signaling protein (MAVS) in detecting HDV and underscores the importance of this model for developing new treatments for hepatitis-related diseases.
The unequivocal identification of hepatitis C virus (HCV) subtypes 1a/1b and genotypes 2 to 6 is required for optimizing the effectiveness of interferon-free, direct-acting antiviral therapies. We compared the performance of a new real-time HCV genotyping assay used on the Cobas 4800 system (C4800) with that of high-resolution HCV subtyping (HRCS). In total, 502 samples were used, including 184 samples from chronic HCV patients (from routine laboratory activity during April 2016), 5 stored samples with double HCV genotype infections for testing the limitations of the method, and 313 samples from a screening protocol implemented in our hospital (from May to August 2016) based on the new method to further determine its genotyping accuracy.
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