A Quest for New Cancer Diagnosis, Prognosis and Prediction Biomarkers and Their Use in Biosensors Development.

Traditional techniques for cancer diagnosis, such as nuclear magnetic resonance, ultrasound and tissue analysis, require sophisticated devices and highly trained personnel, which are characterized by elevated operation costs. The use of biomarkers has emerged as an alternative for cancer diagnosis, prognosis and prediction because their measurement in tissues or fluids, such as blood, urine or saliva, is characterized by shorter processing times. However, the biomarkers used currently, and the techniques used for their measurement, including ELISA, western-blot, polymerase chain reaction (PCR) or immunohistochemistry, possess low sensitivity and specificity.

Crystalline Structure, Synthesis, Properties and Applications of Potassium Hexatitanate: A Review.

Potassium hexatitanate (PHT) with chemical formula KTiO has a tunnel structure formed by TiO octahedra sharing edges or corners and with the potassium atoms located in the tunnels. This material has attracted great interest in the areas of photocatalysis, reinforcement of materials, biomaterials, etc. This work summarizes a large number of studies about methods to prepare PHT since particle size can be modified from millimeter to nanometric scale according to the applied method.