Publications by authors named "Alicia Reyes-Valenzuela"
Article Synopsis
- The study addresses limitations of current lung organoid models by creating organoids from accessible tracheal/bronchial primary cells, improving cellular diversity and structure resemblance to the human lung.
- The new organoids demonstrate transregional differentiation, express various lung region markers, and maintain a mature proteomic profile, making them suitable for respiratory research.
- Successful infection of these organoids with respiratory viruses like SARS-CoV-2 and influenza H1N1 suggests their potential for studying viral infections and developing in-vitro therapies.
Nucleases present a formidable barrier to the application of nucleic acids in biology, significantly reducing the lifetime of nucleic acid-based drugs. Here, we develop a novel methodology to protect DNA and RNA from nucleases by reconfiguring their supramolecular structure through the addition of a nucleobase mimic, cyanuric acid. In the presence of cyanuric acid, polyadenine strands assemble into triple helical fibers known as the polyA/CA motif.
View Article and Find Full Text PDFObjective: Most acellular injectable biomaterials for vocal fold (VF) wound treatment have limited regenerative potential due to their fast enzymatic degradation and limited recruitment of native cells postinjection. The injection of cells as therapeutic treatment often results in apoptosis due to stresses within the needle and the immune response of the host. Degradable microspheres may improve treatment effectiveness by increasing cell residence time, shielding cells during injection, and offering early protection against the immune system response.
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