Publications by authors named "Alicia Rakotonirainy"
Inferring the initiation and development of myeloproliferative neoplasms.
Proc Natl Acad Sci U S A
September 2022
Article Synopsis
- Blood cancer development starts with mutations and the growth of malignant cell clones, primarily occurring in hematopoietic stem cells that are hard to study directly in living organisms.
- We suggest using mathematical modeling and statistical methods to analyze how the disease begins and progresses over time, which can help overcome observational challenges.
- Our research indicates that mutations usually appear later in life and highlights the faster growth rate of malignant clones, showing how these techniques can aid in creating early screening strategies.