Effectiveness of energy-restricted diets with different protein:carbohydrate ratios: the relationship to insulin sensitivity.

Objective: Insulin sensitivity could determine the effectiveness of weight-loss diets with different protein:carbohydrate ratios. Our aim was to evaluate whether or not energy-restricted diets with different protein:carbohydrate ratios in obese individuals with (IR) or without (IS) insulin resistance could lead to differences in weight loss or insulin sensitivity.

Design: Prospective, randomized, clinical intervention study.