Publications by authors named "Alicia P L Chong"
Article Synopsis
- Brugada syndrome (BrS) is a rare hereditary heart condition often linked to mutations in the SCN5A gene, which plays a critical role in sodium ion channel function; it is responsible for 15-30% of cases.
- A young male proband experienced syncopal episodes and was found to carry two mutations in the SCN5A gene inherited from his parents, leading to significant abnormalities during stress testing and a high risk for dangerous heart rhythms.
- This study highlights the unique presentation of compound heterozygote mutations in a Singaporean Chinese family, suggesting variations in how BrS manifests in different populations.
Introduction: Apolipoprotein E (ApoE) is implicated in the pathogenesis of osteoporosis.
Objective: To investigate possible association of the non-classical APOE gene +113C/G (rs440446) intron 1 enhancer polymorphism with bone mineral density (BMD) in a homogeneous Chinese population in Singapore.
Methods: A total of 655 volunteers, males and females, aged between 31 and 72 years, from the public participated.