Sandwiched White Adipose Tissue: A Microphysiological System of Primary Human Adipose Tissue.

White adipose tissue (WAT) is a critical organ in both health and disease. However, physiologically faithful tissue culture models of primary human WAT remain limited, at best. In this study we describe a novel WAT culture system in which primary human WAT is sandwiched between tissue-engineered sheets of adipose-derived stromal cells.

Intrinsic HER4/4ICD transcriptional activation domains are required for STAT5A activated gene expression.

The epidermal growth factor receptor family member HER4 undergoes proteolytic processing at the cell surface to release the HER4 intracellular domain (4ICD) nuclear protein. Interestingly, 4ICD directly interacts with STAT5 and functions as an obligate STAT5 nuclear chaperone. Once in the nucleus 4ICD binds with STAT5 at STAT5 target genes, dramatically potentiating STAT5 transcriptional activation.

Prevalence and correlates of probable adolescent mental health problems reported by parents in Vietnam.

Purpose: The purpose of the present study was to estimate the prevalence of probable mental health problems in an epidemiologic study of Vietnamese adolescents. A secondary aim was to examine the correlates of probable mental health caseness.

Methods: Interviewers visited 1,914 households that were randomly selected to participate in a multi-agency study of mental health in select provinces of Vietnam.

The relationship between battered women's causal attributions for violence and coping efforts.

This study investigates the relationship between battered women's causal attributions for the violence they experience and their subsequent coping efforts. Causal attributions related to partner blame, excusing the violence, and the combination of partner blame and excusing the violence were regressed on six categories of coping strategies: placating, resistance, formal help source, informal help source, safety planning, and legal strategies. Of the 793 women approached outside of a battered women's shelter and the district court, 406 women completed the baseline measure.