Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure.

The thermogenic activity of interscapular brown adipose tissue (IBAT) in response to physiologic stimuli, such as cold exposure, is controlled by its sympathetic innervation. To determine which brain regions might be involved in the regulation of cold-evoked increases in sympathetic outflow to IBAT, the present study compared central nervous system (CNS) areas activated by cold exposure with brain regions anatomically linked to the sympathetic innervation of IBAT. Immunocytochemical localization of Fos was examined in the brains of rats exposed to 4 degrees C for 4 hours.

The locus coeruleus, Barrington's nucleus, and neural circuits of stress.

Much attention has focused on the role of the locus coeruleus (LC) as a component of the central neural circuitry involved in stress. Many, though not all, stressful stimuli produce activation of LC neurons, as reflected by increased Fos expression in these neurons. Stimulation of the LC elicits many stress-like responses, including increased ACTH secretion, though not all responses to LC stimulation are readily interpretable in the context of stress.