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Publications by authors named "Alicia Langer"

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Right Ventricular Hypertrophy in Spontaneously Hypertensive Rats (SHR/NHsd) Is Associated with Inter-Individual Variations of the Pulmonary Endothelin System.
Alicia Langer Rolf Schreckenberg Klaus-Dieter Schlüter

Biology (Basel)

September 2024

Article Synopsis
  • A study found that 7% of spontaneously hypertensive rats (SHRs) develop severe right ventricular hypertrophy (RVH) alongside left ventricular hypertrophy, indicating that RVH can occur independently.
  • Researchers examined the molecular characteristics of the lungs and right ventricles of SHR rats with RVH and compared them to both SHRs with only left ventricular hypertrophy and normotensive rats.
  • Results indicated low expression of the endothelin-B receptor in the lungs of SHR rats with RVH, suggesting it might lead to increased vascular resistance and subsequently trigger RVH, marking the first genetic variant described in this specific SHR strain.
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