Femtosecond laser lenticule transplantation in rabbit cornea: experimental study.

Purpose: To evaluate the feasibility of femtosecond laser-induced lenticule transplantation in the rabbit cornea and to observe the relative histologic characteristics of corneal tissue and nerve repair after transplantation.

Methods: Eight healthy, purebred, New Zealand white rabbits underwent femtosecond laser small-incision lenticule extraction (SMILE) surgery in the right eye. Lenticules were inserted into a femtosecond laser-created corneal stromal pocket in the left eye, which was defined as femtosecond laser corneal lenticule transplantation.

The effect of segment selection on acoustic analysis.

Objective/hypothesis: Acoustic analysis is a commonly used method for quantitatively measuring vocal fold function. Voice signals are analyzed by selecting a waveform segment and using various algorithms to arrive at parameters such as jitter, shimmer, and signal-to-noise ratio (SNR). Accurate and reliable methods for selecting a representative vowel segment have not been established.

A new method of reconstructing the human laryngeal architecture using micro-MRI.

Objectives/hypothesis: A realistic three-dimentional (3D) model of the larynx could be of value for the understanding of normal laryngeal motion and for studying pathological changes as well as in modeling potential therapy outcomes. The objective of this research was to present a new method of creating a computer model of the human larynx using data obtained through micro-magnetic resonance imaging (MRI) scanning.

Study Design: Prospective study.

Implantation of gelatin sponge combined with injection of autologous fat for sulcus vocalis.

Objective: To evaluate the effectiveness of gelatin sponge implantation combined with the injection of autologous fat for the treatment of sulcus vocalis.

Study Design: Prospective cohort study.

Setting: The research was conducted at the Eye, Ear, Nose, and Throat Hospital of Fudan University.

Perturbation and nonlinear dynamic analysis of adult male smokers.

Objective: Smoking results in a voice change, and the perception by smokers of an abnormal voice may encourage quitting behavior. Moreover, a disordered voice is often the first sign of vocal pathology. Efforts to evaluate voice have focused on classical acoustic analysis; however, nonlinear dynamic analysis has been shown to be a reliable objective method for the evaluation of voice.

Transoral laser surgery for anterior commissure involvement: a study in canines.

Objective: To present laser surgery techniques to address anterior commissure involvement and evaluate recovery.

Methods: Twelve canines were divided into three groups. In group A the right ventricular band and vocal fold, the anterior third of the left vocal fold, and anterior commissure were cauterized.

Inhibitory effect on LPS-induced retinal microglial activation of downregulation of t-PA expression by siRNA interference.

Purpose: This study investigated the expression and release of tissue plasminogen activator (t-PA) in lipopolysaccharide (LPS)-induced retinal microglia activation. We evaluated change in microglia activation following down-regulation of t-PA expression by siRNA interference.

Methods: The primary cultured microglia cells were isolated from retinas of S-D rats and activated with different concentration of LPS (0, 3, 10, 30, 100, and 300 ng/ml).

Phonation threshold flow measurements in normal and pathological phonation.

Objectives/hypothesis: Phonation threshold flow (PTF) may provide a tool to assess laryngeal function and could differentiate between normal and pathological voices. Both polyps and nodules contribute to an increased PTF by creating an incomplete glottal closure and increased vocal fold mass and thickness.

Study Design: Prospective study.