Publications by authors named "Alicia J Schade"
The interaction of the platelet glycoprotein (GP) Ib-IX-V complex with von Willebrand factor (VWF) is a critical step in the adhesion of platelets to the subendothelial matrix following endothelial cell damage, particularly under arterial flow conditions. In the human GP Ib-IX-V complex, the recognition of VWF appears to be mediated entirely by GP Ibalpha, the largest of four GP Ib-IX-V polypeptides. The goal of the present study was to investigate the involvement of the cytoplasmic domain of GP Ibalpha in the GP Ib-IX-VWF interaction under both static conditions and in the presence of high fluid shear stress.
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- TTP is a serious blood disorder characterized by the formation of small blood clots in the microvasculature due to a lack of ADAMTS-13, which normally regulates VWF levels.
- The accumulation of ultralarge VWF multimers leads to abnormal attachment to platelets, forming structures under fluid shear stress, which can impede blood flow.
- Cleavage of these structures by ADAMTS-13 occurs quickly in normal plasma but is significantly delayed in TTP patients, demonstrating a crucial physiological process that is disrupted in this condition.