Beware the Iron Rich Gravel: Implications for MRI Safety in Australia.

Through this case report of a child with intra-orbital and intra-cranial iron-rich gravel foreign bodies, shown on our testing to be strongly ferromagnetic, we aim to raise awareness about the potential for these environmental foreign bodies, which are ubiquitous in Australia, to cause serious harm to patients who undergo MRI. Importantly, environmental foreign bodies of very high (metallic) attenuation on CT should be treated as potentially MRI unsafe until proven otherwise.

Mammography diagnostic reference levels in Western Australia.

Mammography dose data has been collected from Western Australian units to establish Diagnostic Reference Levels for the state. Reference levels have been determined for a variety of phantom thicknesses for both full field digital mammography units and digital breast tomosynthesis units. Levels for the American College of Radiology (ACR) Phantom have been established as 1.

GRK2 and Beta-Arrestins in Cardiovascular Disease: Established and Emerging Possibilities for Therapeutic Targeting.

Heptahelical G protein-coupled receptors, such as the -adrenergic and the angiotensin II type 1 receptors, are the most diverse and therapeutically important family of receptors in the human genome, playing major roles in the physiology of various organs/tissues including the heart and blood vessels. Ligand binding activates heterotrimeric G proteins that transmit intracellular signals by regulating effector enzymes or ion channels. G protein signaling is terminated, in large part, by phosphorylation of the agonist-bound receptor by the family of G-protein coupled receptor kinases (GRKs), with GRK2 being its most prominent member, followed by barrestin binding, which uncouples the phosphorylated receptor and G protein and subsequently targets the receptor for internalization.