Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication.

Understanding how injury to the central nervous system induces de novo neurogenesis in animals would help promote regeneration in humans. Regenerative neurogenesis could originate from glia and glial neuron-glia antigen-2 (NG2) may sense injury-induced neuronal signals, but these are unknown. Here, we used to search for genes functionally related to the homologue and identified required in neurons for insulin secretion.