Publications by authors named "Alicia Francis"
Article Synopsis
- - The National Cancer Institute's CPTAC focuses on analyzing tumors using a proteogenomic approach, which combines genomic data with proteomic information to better understand cancer.
- - The consortium has developed a comprehensive dataset that includes genomic, transcriptomic, proteomic, and clinical data from over 1000 tumors across 10 different groups, aimed at enhancing cancer research.
- - The CPTAC team addresses challenges in integrating and analyzing multi-omics data, especially the complexities arising from combining nucleotide sequencing with mass spectrometry proteomics information.
Background: The placenta is a maternal-fetal organ that develops during pregnancy and provides nutrients, oxygen, and removal of waste products to the growing fetus. Better understanding of the placenta promises to help improve health of mothers and children, given its influence on health lasting a lifetime. However, the placenta is poorly understood due to its variability across different species and no live functions available after the baby is delivered.
View Article and Find Full Text PDFCharacterization of Novel Reoviruses Wad Medani Virus (Orbivirus) and Kundal Virus (Coltivirus) Collected from Ticks in India during Surveillance for Crimean Congo Hemorrhagic Fever.
J Virol
July 2019
Article Synopsis
- In 2011, researchers collected ticks from livestock in Gujarat, India, after a Crimean Congo hemorrhagic fever outbreak, leading to the isolation of two new viruses: Karyana virus (KARYV) and Kundal virus (KUNDV).
- Traditional methods failed to identify the viruses, but next-generation sequencing revealed KARYV as a novel strain related to Wad Medani virus and classified KUNDV as a new species due to its genetic similarities with other tick-borne viruses.
- The study underscores the potential threat of these newly discovered viruses to human and animal health, highlighting the importance of continuous surveillance for tick-borne pathogens.
Next-generation sequencing (NGS) of agents causing idiopathic human diseases has been crucial in the identification of novel viruses. This study describes the isolation and characterization of two novel orthobunyaviruses obtained from a jungle myna and a paddy bird from Karnataka State, India. Using an NGS approach, these isolates were classified as Cat Que and Balagodu viruses belonging to the Manzanilla clade of the Simbu serogroup.
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