Publications by authors named "Alicia Cabrera-Martin"
Several neuropeptides present in bone tissues, produced by nerve fibers and bone cells, have been reported to play a role in regulating the fine-tuning of osteoblast and osteoclast functions to maintain bone homeostasis. This study aims to characterize the influence of the neuropeptide vasoactive intestinal peptide (VIP) on the differentiation process of human mesenchymal stem cells (MSCs) into osteoblasts and on their anabolic function. We describe the mRNA and protein expression profile of VIP and its receptors in MSCs as they differentiate into osteoblasts, suggesting the presence of an autocrine signaling pathway in these cells.
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- Naïve CD4 T cells require different signals during activation to elicit a proper immune response, and this study focused on their behavior after stimulation for 14 days.
- The findings revealed that activated CD4 T cells showed increased glucose needs and developed a pathogenic Th17 profile, indicating a potential flexibility towards a Th17/1 phenotype, while regulatory T cells did not appear functional.
- The study also highlighted the role of the vasoactive intestinal peptide (VIP) system, which was found to modulate gene expressions related to Th17 stabilization and plasticity, underlining VIP's importance in T cell responses in various conditions.