Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats.

Repeated stress is an important risk factor for the development of depression. However, the mechanism by which stress influences depression is largely unknown, in part due to the fact that few animal models of repeated stress produce robust changes in depression-like behavior. The purpose of the present study was to characterize the effect of repeated corticosterone (CORT) injections and repeated restraint stress on anxiety and depression-like behavior in male rats.

Kindling-induced emotional behavior in male and female rats.

Modeling fear in animals is a critical approach for identifying the neural mechanisms involved in human disorders such as generalized anxiety and panic. Amygdala kindling has proven useful in this regard because it produces dramatic increases in fearful behavior. The purpose of this experiment was to compare the behavioral effects of kindling in male and female rats.