Publications by authors named "Alicia Berkvens"
Article Synopsis
- The regulation of metabolic protein expression is influenced by genetic circuits that respond to metabolic needs and environmental changes to optimize metabolic fitness.
- Understanding these regulatory mechanisms can inform synthetic biology by helping to design effective synthetic circuits for biotechnological applications.
- The review discusses an approach to design genetic circuits that optimize metabolic networks, focusing on E. coli's regulation of ribosome expression and amino acid biosynthesis, which appear to have evolved for maximum efficiency in protein use.
Microbial populations often contain persister cells, which reduce the extinction risk upon sudden stresses. Persister cell formation is deeply intertwined with physiology. Due to this complexity, it cannot be satisfactorily understood by focusing only on mechanistic, physiological or evolutionary aspects.
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- The study examines the effect of oral butyrate supplementation on glucose regulation and immune response in individuals with long-term type 1 diabetes, given the link between gut microbiota and disease pathology.
- In a double-blind, controlled trial with 30 participants, daily doses of sodium butyrate (4g) or placebo were administered for one month, assessing various immune and metabolic outcomes.
- Results showed that while butyrate supplementation increased levels of certain gut metabolites, it did not produce significant changes in immune function or metabolic markers in the participants.