Are There More HER2 FISH in the Sea? An Institution's Experience in Identifying HER2 Positivity Using Fluorescent In Situ Hybridization in Patients with HER2 Negative Immunohistochemistry.

Background: Approximately 20% of breast cancers express HER2-positive receptors in the USA. HER2 receptor immunohistochemistry (IHC) staining with equivocal (2+) results commonly undergoes fluorescence in-situ hybridization (FISH) for further classification. Current guidelines do not recommend routine FISH testing in IHC-negative (0 or 1+) cases.

Postoperative Surgicel mimicking abscesses following cholecystectomy and liver biopsy.

In postoperative patients presenting with abdominal pain or fever, a computed tomography (CT) finding of gas in the operative site raises concern for abscess but can be mimicked by the normal postoperative appearance of oxidized regenerated cellulose (Surgicel). Information about the operative use of Surgicel and its location is important for accurate CT interpretation of postoperative studies. This case illustrates a scenario in which knowledge of the use of Surgicel offered an explanation for the CT findings, resulting in successful conservative management.