Publications by authors named "Alicia Anton"
The Hodgkin lymphoma (HL) genomic landscape is hardly known due to the scarcity of tumour cells in the tissue. Liquid biopsy employing circulating tumour DNA (ctDNA) can emerge as an alternative tool for non-invasive genotyping. By using a custom next generation sequencing (NGS) panel in combination with unique molecule identifiers, we aimed to identify somatic variants in the ctDNA of 60 HL at diagnosis.
View Article and Find Full Text PDFFollicular lymphoma (FL) is a heterogeneous disease whose pathogenesis remains partially unknown. Around 20% of FL patients experience early progression or treatment-refractory disease and 2-3% of patients per year experience histological transformation (HT) into a more aggressive lymphoma (tFL). Here, we evaluate the immunoglobulin heavy chain variable (IGHV) gene usage and mutational status in 187 FL cases to assess its impact on clinical outcome and histological transformation.
View Article and Find Full Text PDFIntroduction: Molecular alterations leading progression of asymptomatic CLL-like high-count monoclonal B lymphocytosis (hiMBL) to chronic lymphocytic leukemia (CLL) remain poorly understood. Recently, genome-wide association studies have found 6p21.3, where the human leukocyte antigen (HLA) system is coded, to be a susceptibility risk region for CLL.
View Article and Find Full Text PDFDetection of MYD88 L265P mutation by real-time allele-specific oligonucleotide polymerase chain reaction.
Appl Immunohistochem Mol Morphol
July 2015
Article Synopsis
- * The study developed a real-time PCR method (ASO-RQ-PCR) to detect this mutation, demonstrating high sensitivity and reproducibility through experiments with known samples.
- * Results show that this detection method can quantitatively measure tumor burden and effectively differentiate mutated from unmutated cases, presenting ASO-RQ-PCR as a cost-effective tool for diagnosing B-cell disorders.