Obesity Promotes Marrow-Derived Myeloid Cell Accumulation while Exercise Reduces Proliferative Signaling in Colon Cancer.

Purpose: Obesity increases colon cancer risk that has been previously linked to marrow-derived myeloid cells. We previously demonstrated that exercise training (EX) prevents colon cancer initiation, potentially through reduced myelopoiesis. However, it remains unknown whether early myeloid cell accumulation and inflammation in the colon precedes carcinogenesis with high-fat diet (HFD)-induced obesity, and if EX can attenuate these effects.

Getting it right: caring for people who self-harm.

The treatment received in emergency departments by people who self-harm depends to a great extent on the behaviour of staff and how this is perceived by service users. In this article, a long-time service user describes how she was pleasantly surprised by the attitudes of the emergency nurses and doctors who cared for her after she had self-harmed.