Publications by authors named "Alice Tamara"
Objective: Blood culture (BC) sampling is recommended for all suspected sepsis patients prior to antibiotic administration. We examine barriers and enablers to BC sampling in three Southeast Asian countries.
Design: A Theoretical Domains Framework (TDF)-based survey, comprising a case scenario of a patient presenting with community-acquired sepsis and all 14 TDF domains of barriers/enablers to BC sampling.
Objectives: To identify and summarize existing global knowledge gaps on antimicrobial resistance (AMR) in human health, focusing on the World Health Organization (WHO) bacterial priority pathogens, Mycobacterium tuberculosis, and selected fungi.
Methods: We conducted a scoping review of gray and peer-reviewed literature, published in English from January 2012 through December 2021, that reported on the prevention, diagnosis, treatment, and care of drug-resistant infections. We extracted relevant knowledge gaps and, through an iterative process, consolidated those into thematic research questions.
Background: Since December 2019, the world has struggled with the COVID-19 pandemic. Even after the introduction of various vaccines, this disease still takes a considerable toll. In order to improve the optimal allocation of resources and communication of prognosis, healthcare providers and patients need an accurate understanding of factors (such as obesity) that are associated with a higher risk of adverse outcomes from the COVID-19 infection.
View Article and Find Full Text PDFBackground: In spite of clinical progress, cardiovascular disease (CVD) remains the predominant cause of mortality worldwide. Overexpression studies in animals have proven miR-424-5p to have anti-angiogenic properties. As type 1 diabetes mellitus (T1DM) without CVD displays endothelial dysfunction and reduced circulating endothelial progenitor cells (cEPCs), it offers a model of subclinical CVD.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to explore how admission blood glucose levels (both fasting and random) can predict COVID-19 outcomes such as mortality and severity of the disease.
- - An analysis of 35 studies involving over 14,500 patients found a significant link between higher admission fasting blood glucose (FBG) levels and worse COVID-19 prognosis, specifically showing a 33% increased risk of severity for each 1 mmol/L increase in FBG.
- - Although high-quality evidence supported the FBG association with severity, the findings for random blood glucose (RBG) were less conclusive due to fewer studies, indicating a need for more research on both measures' prognostic values in COVID-19.
Association Between Ethnicity and Severe COVID-19 Disease: a Systematic Review and Meta-analysis.
J Racial Ethn Health Disparities
December 2021
Objectives: This article evaluates if ethnicity is an independent poor prognostic factor in COVID-19 disease.
Methods: MEDLINE, EMBASE, Cochrane, WHO COVID-19 databases from inception to 15/06/2020 and medRxiv. No language restriction.
Cardiovascular disease (CVD) correlates with inflammation and a reduction in circulating endothelial progenitor cells (cEPCs). Recently, CVD was shown to be the main cause of mortality in individuals with type 1 diabetes (T1DM). In animals, miR-342 was shown to exert an anti-inflammatory effect in CVD.
View Article and Find Full Text PDFObesity as a predictor for a poor prognosis of COVID-19: A systematic review.
Diabetes Metab Syndr
July 2020
Article Synopsis
- COVID-19, caused by the 2019-novel coronavirus, poses significant health risks, particularly for individuals with obesity who have compromised immune systems, increasing their vulnerability to infection and severe outcomes.
- A systematic review of studies found that obesity significantly raises the likelihood of requiring advanced medical care, with one high-quality study showing patients with a BMI over 35 kg/m² had a seven-fold higher chance of needing invasive ventilation.
- The findings underscore that obesity is a crucial independent risk factor for severe COVID-19 outcomes, highlighting the need for targeted treatment and prevention strategies for this at-risk group.