Synopsis of recent research by authors named "Alice Sharman"
- Alice Sharman's recent research primarily focuses on the development and evaluation of novel pharmacological treatments for schizophrenia, particularly through the study of Kv3 potassium channel modulators like AUT00206, which aims to enhance dopamine synthesis and improve the reliability of imaging techniques such as [F]-FDOPA.
- The studies highlight the significance of targeting reward system abnormalities in schizophrenia, using functional magnetic resonance imaging to examine the effects of AUT00206 on striatal activation during reward anticipation, signifying a potential therapeutic approach in addressing dopaminergic dysfunction.
- Sharman also conducts research outside of schizophrenia, as shown in the QUIET-1 trial, where the efficacy and safety of AUT00063 for treating subjective tinnitus were investigated, revealing the candidate's ability to modulate central auditory cortical neuron activity in preclinical models and setting the stage for future human studies.
